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Core muscle strength may not immediately adapt to changing body composition, potentially causing increased mechanical stress on the lumbar spine, though this mechanism remains hypothetical for pharmacologic weight loss
Low vitamin D can cause symptoms like fatigue, bone or muscle aches, and in severe cases, weak bones
The CMS BALANCE model offers states a path to expand coverage: states can opt into the model between May 2026 and January 2027, and CMS will negotiate lower drug pricing with manufacturers on behalf of participating states
Safety monitoring should include periodic IGF-1 levels and fasting glucose checks, as growth hormone stimulation can affect glucose metabolism
Semaglutide GLP-1 works by mimicking the naturally occurring hormone GLP-1, which plays a crucial role in blood sugar regulation
Clinical trials have demonstrated that semaglutide produces substantial weight loss when combined with lifestyle modifications including reduced caloric intake and increased physical activity
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